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GLP-1 agonists reduce appetite, modulate satiety circuits, alter hepatic lipid handling, improve endothelial function, attenuate inflammatory tone, influence microglial behavior, and appear to exert downstream neuroprotective effects, yet the field cannot convincingly articulate how these effects relate to one another, which are primary versus secondary, or which are merely correlative epiphenomena arising from broader systemic shifts

However, a recently published study showed that excessive iodine levels lead to cell growth inhibition, oxidative stress, and cellular apoptosis in pancreatic beta cells (55)

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\Safety Profile: Avoids corticosteroid-like immunosuppression

Obesity is associated with impaired adipose tissue mitochondrial function and a reduction in circadian clock genes in adipose tissue 1,22,23